Latt, Nang Khaing Zar, Calvert, Peter and Lip, Gregory YH 
ORCID: 0000-0002-7566-1626
(2023)
Balancing the risk of stroke and bleeding in atrial fibrillation patients with a history of falls.
Expert opinion on drug safety, 22 (11).
pp. 1041-1048.
Abstract
<h4>Introduction</h4>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and can lead to serious consequences such as ischemic stroke and systemic thromboembolism. The risk of thromboembolism can be reduced by anticoagulation, however many patients with high falls risk do not receive oral anticoagulation.<h4>Areas covered</h4>In this narrative literature review, performed with searches of the PubMed database, we discuss the factors predisposing AF patients to falls, ways to optimize bleeding risk with individualized assessment, and clarify misconceptions around falls risk and anticoagulation therapy.<h4>Expert opinion</h4>In general, the advantages of stroke prevention with oral anticoagulation outweigh the risk of bleeding resulting from falls, especially with the increasing use of non-vitamin K oral anticoagulants, which are associated with fewer intracranial hemorrhages and thromboembolic complications than vitamin K anticoagulants. Most studies in this field are observational and randomized controlled studies would be beneficial.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Atrial Fibrillation, Thromboembolism, Hemorrhage, Anticoagulants, Administration, Oral, Stroke |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Nov 2023 16:04 |
| Last Modified: | 09 Dec 2023 00:09 |
| DOI: | 10.1080/14740338.2023.2273333 |
| Open Access URL: | https://doi.org/10.1080/14740338.2023.2273333 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3176916 |
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