Boruah, Abhilasha P, Thakur, Kiran T, Gadani, Sachin P, Kothari, Kavita U, Chomba, Mashina, Guekht, Alla, Heydari, Kimia, Hoo, Fan Kee, Hwang, Soonmyung, Michael, Benedict D 
ORCID: 0000-0002-8693-8926 et al (show 9 more authors)
(2023)
Pre-existing neurological conditions and COVID-19 co-infection: Data from systematic reviews, meta-analyses, and scoping reviews.
Journal of the Neurological Sciences, 455.
p. 120858.
Abstract
<h4>Background</h4>Pre-existing neurological diseases have been identified as risk factors for severe COVID-19 infection and death. There is a lack of comprehensive literature review assessing the relationship between pre-existing neurological conditions and COVID-19 outcomes. Identification of high risk groups is critical for optimal treatment and care.<h4>Methods</h4>A literature review was conducted for systematic reviews, meta-analyses, and scoping reviews published between January 1, 2020 and January 1, 2023. Literature assessing individuals with pre-existing neurological diseases and COVID-19 infection was included. Information regarding infection severity was extracted, and potential limitations were identified.<h4>Results</h4>Thirty-nine articles met inclusion criteria, with data assessing >3 million patients from 51 countries. 26/51 (50.9%) of countries analyzed were classified as high income, while the remaining represented middle-low income countries (25/51; 49.0%). A majority of evidence focused on the impact of cerebrovascular disease (17/39; 43.5%) and dementia (5/39; 12.8%) on COVID-19 severity and mortality. 92.3% of the articles (36/39) suggested a significant association between neurological conditions and increased risk of severe COVID-19 and mortality. Cerebrovascular disease, dementia, Parkinson's disease, and epilepsy were associated with increased COVID severity and mortality.<h4>Conclusion</h4>Pre-existing neurological diseases including cerebrovascular disease, Alzheimer's disease and other dementias, epilepsy, and Parkinson's disease are significant risk factors for severity of COVID-19 infection and mortality in the acute infectious period. Given that 61.5% (24/39) of the current evidence only includes data from 2020, further updated literature is crucial to identify the relationship between chronic neurological conditions and clinical characteristics of COVID-19 variants.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Parkinson Disease, Cerebrovascular Disorders, Dementia, Epilepsy, Coinfection, Systematic Reviews as Topic, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Nov 2023 10:49 |
| Last Modified: | 05 Jan 2024 15:46 |
| DOI: | 10.1016/j.jns.2023.120858 |
| Open Access URL: | https://pubmed.ncbi.nlm.nih.gov/37948972/ |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3176929 |
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