Wheeler, Nicole E 
ORCID: 0000-0003-4599-9164, Price, Vivien ORCID: 0000-0003-3573-5106, Cunningham-Oakes, Edward ORCID: 0000-0003-0260-5508, Tsang, Kara K, Nunn, Jamie G, Midega, Janet T, Anjum, Muna F, Wade, Matthew J, Feasey, Nicholas A, Peacock, Sharon J et al (show 3 more authors)
(2023)
Innovations in genomic antimicrobial resistance surveillance.
The Lancet. Microbe, 4 (12).
e1063-e1070.
Abstract
Whole-genome sequencing of antimicrobial-resistant pathogens is increasingly being used for antimicrobial resistance (AMR) surveillance, particularly in high-income countries. Innovations in genome sequencing and analysis technologies promise to revolutionise AMR surveillance and epidemiology; however, routine adoption of these technologies is challenging, particularly in low-income and middle-income countries. As part of a wider series of workshops and online consultations, a group of experts in AMR pathogen genomics and computational tool development conducted a situational analysis, identifying the following under-used innovations in genomic AMR surveillance: clinical metagenomics, environmental metagenomics, gene or plasmid tracking, and machine learning. The group recommended developing cost-effective use cases for each approach and mapping data outputs to clinical outcomes of interest to justify additional investment in capacity, training, and staff required to implement these technologies. Harmonisation and standardisation of methods, and the creation of equitable data sharing and governance frameworks, will facilitate successful implementation of these innovations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SEDRIC Genomics Surveillance Working Group, Humans, Anti-Bacterial Agents, Genomics, Drug Resistance, Bacterial, Genome, Whole Genome Sequencing |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 27 Nov 2023 09:22 |
| Last Modified: | 02 Apr 2024 09:30 |
| DOI: | 10.1016/s2666-5247(23)00285-9 |
| Open Access URL: | https://doi.org/10.1016/S2666-5247(23)00285-9 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3177006 |
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