A Darwinian View of Behçet's Disease.

Smith, Rhodri, Moots, Robert J ORCID: 0000-0001-7019-6211, Murad, Mariam and Wallace, Graham R (2021) A Darwinian View of Behçet's Disease. Rheumatology and immunology research, 2 (2). pp. 91-99.

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Abstract

Behçet's disease (BD) is a multisystem inflammatory disorder of unknown etiology, characterized by oral and genital ulceration, with other complications including eye, skin, joint, and central nervous system (CNS) lesions. Diagnosis is based on clinical findings, which may differ between patients. There is a strong genetic basis for BD; however, only a few genes have been associated with the disease across the geographical spread of BD. In this article, we discuss the history and combination of genes involved in this complex disease in relation to the geographical range and present our view that the disease has developed from a Darwinian perspective, with different gene polymorphisms that affect the same biological pathway. Moreover, these mutations individually are protective mechanisms against the disease relevant to each region, which affected both archaic and modern humans.

Item Type:	Article
Uncontrolled Keywords:	Behcet’s disease, genes, introgression, neanderthal
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	30 Nov 2023 16:56
Last Modified:	30 Nov 2023 17:32
DOI:	10.2478/rir-2021-0013
Open Access URL:	https://doi.org/10.2478/rir-2021-0013
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3177115