Lin, Jing, Wu, Xue-Ying, Long, De-Yong, Jiang, Chen-Xi, Sang, Cai-Hua, Tang, Ri-Bo, Li, Song-Nan, Wang, Wei, Guo, Xue-Yuan, Ning, Man et al (show 13 more authors)
(2023)
Asymptomatic atrial fibrillation among hospitalized patients: clinical correlates and in-hospital outcomes in Improving Care for Cardiovascular Disease in China-Atrial Fibrillation.
EUROPACE, 25 (10).
euad272-.
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Asymptomatic atrial fibrillation among hospitalized patients clinical correlates and in-hospital outcomes in Improving Care .pdf - Open Access published version Download (380kB) | Preview |
Abstract
<h4>Aims</h4>The clinical correlates and outcomes of asymptomatic atrial fibrillation (AF) in hospitalized patients are largely unknown. We aimed to investigate the clinical correlates and in-hospital outcomes of asymptomatic AF in hospitalized Chinese patients.<h4>Methods and results</h4>We conducted a cross-sectional registry study of inpatients with AF enrolled in the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation Project between February 2015 and December 2019. We investigated the clinical characteristics of asymptomatic AF and the association between the clinical correlates and the in-hospital outcomes of asymptomatic AF. Asymptomatic and symptomatic AF were defined according to the European Heart Rhythm Association score. Asymptomatic patients were more commonly males (56.3%) and had more comorbidities such as hypertension (57.4%), diabetes mellitus (18.6%), peripheral artery disease (PAD; 2.3%), coronary artery disease (55.5%), previous history of stroke/transient ischaemic attack (TIA; 17.9%), and myocardial infarction (MI; 5.4%); however, they had less prevalent heart failure (9.6%) or left ventricular ejection fractions ≤40% (7.3%). Asymptomatic patients were more often hospitalized with a non-AF diagnosis as the main diagnosis and were more commonly first diagnosed with AF (23.9%) and long-standing persistent/permanent AF (17.0%). The independent determinants of asymptomatic presentation were male sex, long-standing persistent AF/permanent AF, previous history of stroke/TIA, MI, PAD, and previous treatment with anti-platelet drugs. The incidence of in-hospital clinical events such as all-cause death, ischaemic stroke/TIA, and acute coronary syndrome (ACS) was higher in asymptomatic patients than in symptomatic patients, and asymptomatic clinical status was an independent risk factor for in-hospital all-cause death, ischaemic stroke/TIA, and ACS.<h4>Conclusion</h4>Asymptomatic AF is common among hospitalized patients with AF. Asymptomatic clinical status is associated with male sex, comorbidities, and a higher risk of in-hospital outcomes. The adoption of effective management strategies for patients with AF should not be solely based on clinical symptoms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atrial fibrillation, Acute coronary syndrome, Hypertension, Stroke |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Nov 2023 17:06 |
| Last Modified: | 30 Nov 2023 17:07 |
| DOI: | 10.1093/europace/euad272 |
| Open Access URL: | https://doi.org/10.1093/europace/euad272 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3177123 |
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