Nithichanon, Arnone, Kamuthachad, Ludthawun, Salao, Kanin 
ORCID: 0000-0003-4731-9556, Phoksawat, Wisitsak, Kamsom, Chatcharin, Wongratanacheewin, Surasakdi, Pipattanaboon, Chonlatip, Kanthawong, Sakawrat, Yordpratum, Umaporn, Aromseree, Sirinart et al (show 4 more authors)
(2023)
A two-arm analysis of the immune response to heterologous boosting of inactivated SARS-CoV-2 vaccines.
Scientific reports, 13 (1).
18762-.
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Abstract
Several vaccine programs were introduced during the COVID-19 pandemic, which included inactivated virus, DNA viral vectors and mRNA vaccines. Booster programs are recommended, especially for those in high-risk groups. However, many of these booster programs involve heterologous vaccines. This study enrolled volunteers who first received two full-dose CoronaVac vaccinations before receiving heterologous boosters with DNA- and/or mRNA-vaccines for an additional 2 doses (n = 40) or an additional 3 doses (n = 16). Our results showed no difference in side effects, neutralizing antibodies, or T-cell responses for any of the heterologous vaccination programs. However, the neutralizing capacity and IFN-γ responses against the Omicron variant in volunteers who received 4 or 5 doses were improved. Polarization of peripheral memory T cells after stimulation in all booster groups with Omicron peptide showed an increased trend of naïve and central memory phenotypes of both CD4+ and CD8+ T cells, suggesting that exposure to Omicron antigens will drive T cells into a lymphoid resident T cell phenotype. Our data support a continuous vaccination program to maximize the effectiveness of immunity, especially in people at high risk. Furthermore, the number of boosting doses is important for maintaining immunity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Vaccines, Inactivated, Antibodies, Viral, Immunity, Antibodies, Neutralizing, Pandemics, COVID-19, SARS-CoV-2, COVID-19 Vaccines |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Dec 2023 11:46 |
| Last Modified: | 13 Dec 2023 11:46 |
| DOI: | 10.1038/s41598-023-46053-8 |
| Open Access URL: | https://doi.org/10.1038/s41598-023-46053-8 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3177306 |
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