Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes


Nguyen, Lam Vuong, Phung, Khanh Lam, Ming, Damien Keng Yen ORCID: 0000-0003-3125-6378, Huynh, Thi Le Duyen, Nguyet, Minh Nguyen, Dong, Thi Hoai Tam, Kien, Duong Thi Hue, Chau, Nguyen VV, Chanpheaktra, Ngoun, Lum, Lucy Chai See et al (show 11 more authors) (2021) Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes. ELIFE, 10. e67460-.

Access the full-text of this item by clicking on the Open Access link.

Abstract

<h4>Background</h4>Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of 10 biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD).<h4>Methods</h4>We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included.<h4>Results</h4>On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults.<h4>Conclusions</h4>Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.<h4>Funding</h4>This study was supported by the EU's Seventh Framework Programme (FP7-281803 IDAMS), the WHO, and the Bill and Melinda Gates Foundation.

Item Type: Article
Uncontrolled Keywords: and the Bill and Melinda Gates Foundation, IDAMS), the WHO, This study was supported by the EU's Seventh Framework Programme (FP7-281803
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 15 Dec 2023 10:43
Last Modified: 26 Jan 2024 16:57
DOI: 10.7554/eLife.67460
Open Access URL: https://doi.org/10.7554/eLife.67460
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3177419
Dimensions
Altmetric
CORE (COnnecting REpositories)