Investigating the Immune Basis of Green Tea Extract Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01.

Line, James ORCID: 0000-0003-3568-8928, Ali, Serat-E, Grice, Sophie ORCID: 0000-0001-8355-4233, Rao, Tai and Naisbitt, Dean J ORCID: 0000-0003-4107-7832 (2023) Investigating the Immune Basis of Green Tea Extract Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01. Chemical research in toxicology, 36 (12). pp. 1872-1875.

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Official URL: http://dx.doi.org/10.1021/acs.chemrestox.3c00253

Abstract

Epigallocatechin-3-O-gallate (EGCG) is the major component of green tea extract, commonly found in dietary supplements, and has been associated with immune-mediated liver injury. The purpose of this study was to investigate the immunogenicity of EGCG in healthy donors expressing HLA-B*35:01, and characterize EGCG responsive T-cell clones. We have shown that EGCG can prime peripheral blood mononuclear cells and T-cells from donors with and without the HLA-B*35:01 allele. T-cell clones were CD4+ve and capable of secreting Th1, Th2, and cytolytic molecules. These data demonstrate that EGCG can activate T-cells in vitro, suggesting a significant role in the pathogenesis of green tea extract induced liver injury.

Item Type:	Article
Uncontrolled Keywords:	Leukocytes, Mononuclear, Humans, Catechin, Plant Extracts, HLA-B Antigens, Antioxidants, Tea, Chemical and Drug Induced Liver Injury, Chronic
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	19 Dec 2023 16:15
Last Modified:	02 Apr 2024 09:30
DOI:	10.1021/acs.chemrestox.3c00253
Open Access URL:	https://doi.org/10.1021/acs.chemrestox.3c00253
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3177546