ROCK Inhibitors in Corneal Diseases and Glaucoma-A Comprehensive Review of These Emerging Drugs.

Pagano, Luca ORCID: 0000-0001-8534-6817, Lee, Jason William, Posarelli, Matteo ORCID: 0000-0002-3983-0381, Giannaccare, Giuseppe ORCID: 0000-0003-2617-0289, Kaye, Stephen ORCID: 0000-0003-0390-0592 and Borgia, Alfredo (2023) ROCK Inhibitors in Corneal Diseases and Glaucoma-A Comprehensive Review of These Emerging Drugs. Journal of clinical medicine, 12 (21). 6736-.

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Official URL: http://dx.doi.org/10.3390/jcm12216736

Abstract

Rho kinase (ROCK) inhibitors have gained significant attention as emerging novel treatment options in the field of ophthalmology in recent years. The evidence supporting their efficacy in glaucoma and corneal pathology includes both in vitro and clinical studies. Among the available options, ripasudil and netarsudil have emerged as the leading ROCK inhibitors, and some countries have approved these therapeutic options as treatments for glaucoma. Various dosing regimens have been studied, including monotherapy and combination therapy, especially for patients with secondary glaucoma who are already on multiple medications. Another rising application of ROCK inhibitors includes their use as an adjunct in surgical procedures such as Descemetorhexis Without Endothelial Keratoplasty (DWEK), Descemet Stripping Only (DSO) to accelerate visual recovery, glaucoma surgeries to reduce scarring process and allow better intraocular pressure (IOP) control, or after complicated anterior segment surgery to treat corneal oedema. This article provides a comprehensive overview of the existing literature in the field, offering recommendations for prescribing ROCK inhibitors and also discussing patient selection, drug efficacy, and possible adverse effects.

Item Type:	Article
Uncontrolled Keywords:	Descemet membrane, cornea guttata, glaucoma, netarsudil, rho kinase, ripasudil
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	21 Dec 2023 16:49
Last Modified:	21 Dec 2023 16:49
DOI:	10.3390/jcm12216736
Open Access URL:	https://doi.org/10.3390/jcm12216736
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3177610