Polymer-prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine.


Liu, Chung, Hern, Faye Y, Shakil, Anika, Temburnikar, Kartik, Chambon, Pierre, Liptrott, Neill ORCID: 0000-0002-5980-8966, McDonald, Tom O ORCID: 0000-0002-9273-9173, Neary, Megan, Flexner, Charles, Owen, Andrew ORCID: 0000-0002-9819-7651 et al (show 2 more authors) (2023) Polymer-prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine. Journal of materials chemistry. B, 11 (48). pp. 11532-11543.

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Abstract

Circulating, soluble polymer-drug conjugates have been utilised for many years to aid the delivery of sensitive, poorly-soluble or cytotoxic drugs, prolong circulation times or minimise side effects. Long-acting therapeutics are increasing in their healthcare importance, with intramuscular and subcutaneous administration of liquid formulations being most common. Degradable implants also offer opportunities and the use of polymer-prodrug conjugates as implant materials has not been widely reported in this context. Here, the potential for polymer-prodrug conjugates of the water soluble nucleoside reverse transciption inhibitor emtricitabine (FTC) is studied. A novel diol monomer scaffold, allowing variation of prodrug substitution, has been used to form polyesters and polycarbonates by step-growth polymerisation. Materials have been screened for physical properties that enable implant formation, studied for drug release to provide mechanistic insights, and tunable prolonged release of FTC has been demonstrated over a period of at least two weeks under relevant physiological conditions.

Item Type: Article
Uncontrolled Keywords: Water, Polymers, DNA-Directed RNA Polymerases, Nucleosides, Prodrugs, Emtricitabine
Divisions: Faculty of Health and Life Sciences
Faculty of Science and Engineering > School of Physical Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 12 Jan 2024 16:53
Last Modified: 19 Jan 2024 14:42
DOI: 10.1039/d3tb02268d
Open Access URL: https://pubs.rsc.org/en/Content/ArticleLanding/202...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3177821
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