Evaluation of systemic inflammation in seizure phenotypes following meningioma resection.

Bakhsh, Ali, Gillespie, Conor S, Richardson, George E, Mustafa, Mohammed A, Millward, Christopher P ORCID: 0000-0001-7727-1157, Mirza, Nasir and Jenkinson, Michael D ORCID: 0000-0003-4587-2139 (2024) Evaluation of systemic inflammation in seizure phenotypes following meningioma resection. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 120. pp. 82-86.

Text 2024_seizures and inflammation meningioma.docx - Author Accepted Manuscript Available under License Creative Commons Attribution. Download (242kB)

Abstract

<h4>Purpose</h4>To investigate the association between perioperative peripheral blood inflammatory markers and seizures in patients who have undergone meningioma resection.<h4>Materials and methods</h4>A single neurosurgery tertiary centre blood bank database was screened to extract pre-operative and post-operative white cell count (WCC), neutrophils, lymphocytes, monocytes, platelets and neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR). All patients who underwent resection of meningioma from 2012 to 2020 were eligible. Patients were excluded if they had an inflammatory condition, peri-operative infection, medical illness or operative complication.<h4>Results</h4>30 patients suffered pre-operative seizures only, 16 experienced de novo post-operative seizures within 1 year and 42 patients did not experience seizures throughout their treatment timeline. Patients with post-operative de novo seizures had a significantly higher WCC when compared those who never had a seizure (7.1 vs. 4.8x10⁹/L, p =.048, 95 % 1.96 to 5.60). However, this difference of WCC was poorly predictive of de novo seizures at one year (AUC 0.61). dNLR was significantly higher in patients with continued post-operative seizures than in patients in which seizures were terminated with tumour resection (1.2 vs. 0.1, p =.035, 95 % 1.47 to 2.29). dNLR was predictive of seizures at one year with an 87.5 % sensitivity and 82.1 % specificity.<h4>Conclusions</h4>There is a significantly higher post-operative systemic white cell count response in patients who suffered de novo seizures after meningioma resection. Peripheral blood markers have the potential to predict seizures in patients with meningioma.

Item Type:	Article
Uncontrolled Keywords:	Neutrophils, Lymphocytes, Humans, Meningioma, Meningeal Neoplasms, Seizures, Inflammation, Prognosis, Retrospective Studies, Phenotype
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	23 Jan 2024 08:47
Last Modified:	17 Feb 2024 02:04
DOI:	10.1016/j.jocn.2024.01.003
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3177956