Antibacterial Activity of River Water Bacteriophage against Multidrug-resistant Gram-negative Bacteria, An In vitro Study

Mohaisen, Mohammed R ORCID: 0000-0002-0329-752X, Lafi, Shehab A and Al-Quhli, Sawasan QT (2023) Antibacterial Activity of River Water Bacteriophage against Multidrug-resistant Gram-negative Bacteria, An In vitro Study. Journal of Pure and Applied Microbiology, 17 (4). pp. 2344-2351.

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Official URL: http://dx.doi.org/10.22207/jpam.17.4.30

Abstract

<jats:p>Microbes show a high antimicrobial resistance due to a high rate of mutations predisposed by many factors, especially the abuse of antibiotics. Therefore, there is a great need for an alternative therapeutic agent for infectious diseases caused by microbes resistant to antibiotics. Bacteriophages are viruses parasitizing microbes, that got a big scientist’s attention due to their ability as an alternative therapy for severe bacterial infections. This study is devoted to identifying bacteriophage from river water on tested pathogenic isolates isolated from clinical cases of UTI in vitro and finding out the effect of phage on these bacterial isolates as an initial step of further in vivo phage therapeutic study on the same tested isolates. The results showed a significant bactericidal effect of the isolated bacteriophages against the pathogenic bacterial isolates.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	Vaccine Related, Infectious Diseases, Prevention, Antimicrobial Resistance, Biodefense, Emerging Infectious Diseases, 5.1 Pharmaceuticals, 2 Aetiology, 5 Development of treatments and therapeutic interventions, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	30 Jan 2024 08:05
Last Modified:	15 Mar 2024 03:01
DOI:	10.22207/jpam.17.4.30
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178062