Earnest, Rebecca, Chen, Christine, Chaguza, Chrispin 
ORCID: 0000-0002-2108-1757, Hahn, Anne M, Grubaugh, Nathan D and Wilson, Madeline S
(2022)
Daily Rapid Antigen Exit Testing to Tailor University COVID-19 Isolation Policy.
EMERGING INFECTIOUS DISEASES, 28 (12).
pp. 2455-2462.
Abstract
We evaluated daily rapid antigen test (RAT) data from 323 COVID-19-positive university students in Connecticut, USA, during an Omicron-dominant period. Day 5 positivity was 47% for twice-weekly screeners and 26%-28% for less-frequent screeners, approximately halving each subsequent day. Testing negative >10 days before diagnosis (event time ratio (ETR) 0.85 [95% CI 0.75-0.96]) and prior infection >90 days (ETR 0.50 [95% CI 0.33-0.76]) were significantly associated with shorter RAT positivity duration. Symptoms before or at diagnosis (ETR 1.13 [95% CI 1.02-1.25]) and receipt of 3 vaccine doses (ETR 1.20 [95% CI 1.04-1.39]) were significantly associated with prolonged positivity. Exit RATs enabled 53%-74% of students to leave isolation early when they began isolation at the time of the first positive test, but 15%-22% remained positive beyond the recommended isolation period. Factors associated with RAT positivity duration should be further explored to determine relationships with infection duration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Yale COVID-19 Resulting and Isolation Team, Humans, Vaccines, Students, Universities, Policy, COVID-19 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Jan 2024 10:37 |
| Last Modified: | 30 Jan 2024 11:12 |
| DOI: | 10.3201/eid2812.220969 |
| Open Access URL: | http://10.0.12.129/eid2812.220969 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178104 |
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