Czarnywojtek, Agata, Pietronczyk, Krzysztof, Thompson, Lester DR, Triantafyllou, Asterios, Florek, Ewa, Sawicka-Gutaj, Nadia, Ruchala, Marek, Plazinska, Maria Teresa, Nixon, Iain J, Shaha, Ashok R et al (show 6 more authors)
(2023)
IgG4-related sclerosing thyroiditis (Riedel-Struma): a review of clinicopathological features and management.
VIRCHOWS ARCHIV, 483 (2).
pp. 133-144.
Abstract
We present a thorough review of the literature on Riedel thyroiditis (RT) with emphasis on aetiology, diagnosis and management, using the PubMed, Sinomed, and China National Knowledge Infrastructure databases. Although the exact aetiology of RT remains obscure, the histopathological features are consistent with a localized form of IgG<sub>4</sub>-related systemic disease (IgG<sub>4</sub>-RSD). Nevertheless, IgG4-RSD as a systemic fibroinflammatory disorder per se rarely affects the thyroid in the context of multiorgan manifestations. The initial diagnosis of RT is based on clinical history and imaging, but confirmation by histopathological examination is mandatory. In contrast to the historical surgical approach, glucocorticosteroid therapy is currently considered first line therapy, in line with the RT currently being viewed as a manifestation of, or analogous to, IgG4-RSD. For disease relapse, immunomodulatory agents (azathioprine, methotrexate, rituximab) can be used.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Fibrosis, Glucocorticoid, Hyperthyroidism, Hypothyroidism, IgG(4)- related systemic disease, Immune system, Mycophenolate mofetil, Riedel thyroiditis, Tamoxifen, Thyroidectomy |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Jan 2024 11:50 |
| Last Modified: | 31 Jan 2024 11:50 |
| DOI: | 10.1007/s00428-023-03561-2 |
| Open Access URL: | https://doi.org/10.1007/s00428-023-03561-2 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178194 |
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