Testi, Ilaria, Brandao-de-Resende, Camilo, Agrawal, Rupesh and Pavesio, Carlos
(2022)
Ocular inflammatory events following COVID-19 vaccination: a multinational case series.
JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION, 12 (1).
4-.
Abstract
<h4>Background</h4>Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine's immunogenicity and safety, especially in patients with pre-existing inflammatory conditions.<h4>Methods</h4>Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021.<h4>Results</h4>Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19-84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1-14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%).<h4>Conclusion</h4>Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Coronavirus disease, COVID-19, Immunomodulatory, Ocular inflammation, SARS-CoV-2, Uveitis, Vaccination |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Feb 2024 09:36 |
| Last Modified: | 01 Feb 2024 09:36 |
| DOI: | 10.1186/s12348-021-00275-x |
| Open Access URL: | https://doi.org/10.1186/s12348-021-00275-x |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178258 |
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