Taneri, Petek Eylul, Kirkham, Jamie J 
ORCID: 0000-0003-2579-9325, Molloy, Eleanor J, Biesty, Linda, Polin, Richard A, Wynn, James L, Stoll, Barbara J, Kissoon, Niranjan, Kawaza, Kondwani, Daly, Mandy et al (show 9 more authors)
(2023)
Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).
PloS one, 18 (12).
e0295325-e0295325.
Abstract
Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients' parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Treatment Outcome, Consensus, Research Design, Delphi Technique, Infant, Newborn, Neonatal Sepsis, Systematic Reviews as Topic, Outcome Assessment, Health Care |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Feb 2024 10:29 |
| Last Modified: | 02 Feb 2024 10:29 |
| DOI: | 10.1371/journal.pone.0295325 |
| Open Access URL: | https://doi.org/10.1371/journal.pone.0295325 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178310 |
Dimensions
Dimensions
