Rapid Diagnostic Test Value and Implementation in Antimicrobial Stewardship Across Low-to-Middle and High-Income Countries: A Mixed-Methods Review

Moore, Luke SP, Villegas, Maria Virginia, Wenzler, Eric, Rawson, Timothy M ORCID: 0000-0002-2630-9722, Oladele, Rita O, Doi, Yohei and Apisarnthanarak, Anucha (2023) Rapid Diagnostic Test Value and Implementation in Antimicrobial Stewardship Across Low-to-Middle and High-Income Countries: A Mixed-Methods Review. INFECTIOUS DISEASES AND THERAPY, 12 (6). pp. 1445-1463.

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Official URL: http://dx.doi.org/10.1007/s40121-023-00815-z

Abstract

Despite technological advancements in infectious disease rapid diagnostic tests (RDTs) and use to direct therapy at the per-patient level, RDT utilisation in antimicrobial stewardship programmes (ASPs) is variable across low-to-middle income and high-income countries. Key insights from a panel of seven infectious disease experts from Colombia, Japan, Nigeria, Thailand, the UK, and the USA, combined with evidence from a literature review, were used to assess the value of RDTs in ASPs. From this, a value framework is proposed which aims to define the benefits of RDT use in ASPs, separate from per-patient benefits. Expert insights highlight that, to realise the value of RDTs within ASPs, effective implementation is key; actionable advice for choosing an RDT is proposed. Experts advocate the inclusion of RDTs in the World Health Organization Model List of essential in vitro diagnostics and in iterative development of national action plans.

Item Type:	Article
Uncontrolled Keywords:	and low-income countries, Antimicrobial resistance, Antimicrobial stewardship, Antimicrobial stewardship programmes, High-, Infectious disease RDT, middle-, Point-of-care testing, Rapid diagnostic tests
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	02 Feb 2024 10:25
Last Modified:	02 Feb 2024 10:25
DOI:	10.1007/s40121-023-00815-z
Open Access URL:	https://doi.org/10.1007/s40121-023-00815-z
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178322