Kailey, Balrik, Kemp, Ian, Taylor, Martika, Crooks, Jennifer, Katritsis, George, Koa-Wing, Michael, Jamil-Copley, Shahnaz, Linton, Nick, Kanagaratnam, Prapa, Gupta, Dhiraj et al (show 1 more authors)
(2023)
Ripple AT Plus - isthmus-guided vs conventional ablation in the treatment of scar-related atrial tachycardia: study protocol for a randomised controlled trial.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 66 (7).
pp. 1533-1539.
Abstract
<h4>Background</h4>Catheter ablation is routinely used to treat scar-related atrial tachycardia (s-AT). Conventional ablation often involves creating anatomical "lines" that transect myocardial tissue supporting reentry. This can be extensive, creating iatrogenic scar as a nidus for future reentry, and may account for arrhythmia recurrence. High-density mapping may identify "narrower isthmuses" requiring less ablation, with ripple mapping proven to be an effective approach in identifying. This trial explores whether ablation of narrower isthmuses in s-AT, defined using ripple mapping, results in greater freedom from arrhythmia recurrence compared to conventional ablation.<h4>Methods</h4>The Ripple-AT-Plus trial (registration ClinicalTrials.gov , NCT03915691) is a prospective, multicentre, single-blinded, randomised controlled trial with 12-month follow-up. Two hundred s-AT patients will be randomised in a 1:1 fashion to either "ripple mapping-guided isthmus ablation" vs conventional ablation on the CARTO3 ConfiDENSE system (Biosense Webster). The primary outcome will compare recurrence of any atrial arrhythmia. Multicentre data will be analysed over a secure web-based cloud-storage and analysis software (CARTONET<sup>TM</sup>).<h4>Conclusion</h4>This is the first trial that considers long-term patient outcomes post s-AT ablation, and whether targeting narrower isthmuses in the era of high density is optimal.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atrial tachycardia, Catheter ablation, Isthmus, Linear ablation |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Feb 2024 11:40 |
| Last Modified: | 02 Feb 2024 11:40 |
| DOI: | 10.1007/s10840-023-01607-8 |
| Open Access URL: | https://doi.org/10.1007/s10840-023-01607-8 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178339 |
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