Boga, Márton ORCID: 0000-0002-1469-9460, Suhai, Ferenc Imre ORCID: 0000-0002-5268-3873, Orbán, Gábor ORCID: 0000-0002-5850-9892, Salló, Zoltán ORCID: 0000-0002-2320-3535, Nagy, Klaudia Vivien ORCID: 0000-0001-6878-1892, Szegedi, Levente ORCID: 0009-0003-8484-0313, Jokkel, Zsófia ORCID: 0000-0002-5407-6540, Csőre, Judit ORCID: 0000-0003-3792-527X, Osztheimer, István ORCID: 0000-0002-8209-990X, Perge, Péter ORCID: 0000-0003-1256-3532 et al (show 4 more authors)
(2023)
Incidence and predictors of stroke and silent cerebral embolism following very high-power short-duration atrial fibrillation ablation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 25 (11).
euad327-.
Abstract
<h4>Aims</h4>Cerebral thrombo-embolism is a dreaded complication of pulmonary vein isolation (PVI) for atrial fibrillation; its surrogate, silent cerebral embolism (SCE) can be detected by diffusion-weighted brain magnetic resonance imaging (bMRI). Initial investigations have raised a concern that very high-power, short-duration (vHPSD; 90 W/4 s) temperature-controlled PVI with the QDOT Micro catheter may be associated with a higher incidence of SCE compared with low-power long-duration ablation. We aimed to assess the incidence of procedural complications of vHPSD PVI with an emphasis on cerebral safety.<h4>Methods and results</h4>We enrolled 328 consecutive patients undergoing their PVI procedure using vHPSD. A subgroup of 61 consecutive patients underwent diffusion-weighted bMRI within 24 h of the procedure, and incidence and predictors of SCE were studied. The mean procedure time and left atrial dwell time for the overall cohort were 69.6 ± 24.1 and 46.5 ± 21.5 min, respectively. First-pass isolation was achieved in 82%. No stroke or transient ischaemic attack occurred. Silent cerebral embolism was identified in 5 of 61 patients (8.2%). Silent cerebral embolism following procedures was significantly associated with lower baseline generator impedance (105.8 vs. 112.6 Ω, P < 0.0001) and with intermittent loss of catheter-tissue contact during ablation (14.1% vs. 6.1%, P < 0.0001).<h4>Conclusion</h4>Very high-power, short-duration PVI is a safe technique with an excellent acute success rate. Silent cerebral embolism incidence in our cohort was below the previously reported range, with no clinically overt cerebral complications. Lower baseline generator impedance and loss of contact during ablation may contribute to a higher risk of SCEs.
Item Type: | Article |
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Uncontrolled Keywords: | Pulmonary Veins, Heart Atria, Humans, Intracranial Embolism, Atrial Fibrillation, Catheter Ablation, Treatment Outcome, Incidence, Stroke |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 06 Feb 2024 09:40 |
Last Modified: | 06 Feb 2024 09:40 |
DOI: | 10.1093/europace/euad327 |
Open Access URL: | https://doi.org/10.1093/europace/euad327 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178417 |