Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria.

Balanza, Núria ORCID: 0000-0002-3581-0383, Francis, Caroline K, Crowley, Valerie M ORCID: 0000-0002-2593-1130, Weckman, Andrea M ORCID: 0000-0002-2200-4008, Zhong, Kathleen, Baro, Bàrbara ORCID: 0000-0001-7780-1744, Varo, Rosauro ORCID: 0000-0003-4282-5572, Bassat, Quique ORCID: 0000-0003-0875-7596, Kain, Kevin C ORCID: 0000-0001-6068-1272 and Rosiglitazone Adjunctive Therapy for Severe Malaria in Children, (2024) Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria. The Journal of infectious diseases, 229 (1). pp. 183-188.

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Abstract

Malaria can cause brain injury. Neurofilament light chain (NfL) is a biomarker of neuronal damage. Here we examined longitudinal plasma NfL levels in children aged 1-12 years with uncomplicated and severe malaria from Mozambique. NfL levels were similar in all malaria cases at hospital admission. However, levels increased over time and the increment was significantly higher in severe malaria cases with neurological manifestations (ie, coma, impaired consciousness, or repeated seizures). NfL may be useful to identify and quantify brain injury in malaria.

Item Type:	Article
Uncontrolled Keywords:	Rosiglitazone Adjunctive Therapy for Severe Malaria in Children (ROSI) Study Group, Intermediate Filaments, Humans, Malaria, Brain Injuries, Seizures, Neurofilament Proteins, Child, Biomarkers
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Feb 2024 09:39
Last Modified:	06 Feb 2024 09:39
DOI:	10.1093/infdis/jiad373
Open Access URL:	https://doi.org/10.1093/infdis/jiad373
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178424