The population-level impact of <i>Enterococcus faecalis</i> genetics on intestinal colonization and extraintestinal infection


Chaguza, Chrispin ORCID: 0000-0002-2108-1757, Poentinen, Anna K, Top, Janetta, Arredondo-Alonso, Sergio, Freitas, Ana R, Novais, Carla, Torres, Carmen, Bentley, Stephen D, Peixe, Luisa, Coque, Teresa M et al (show 2 more authors) (2023) The population-level impact of <i>Enterococcus faecalis</i> genetics on intestinal colonization and extraintestinal infection. MICROBIOLOGY SPECTRUM, 11 (6). e0020123-.

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Abstract

<h4>Importance</h4><i>Enterococcus faecalis</i> causes life-threatening invasive hospital- and community-associated infections that are usually associated with multidrug resistance globally. Although <i>E. faecalis</i> infections cause opportunistic infections typically associated with antibiotic use, immunocompromised immune status, and other factors, they also possess an arsenal of virulence factors crucial for their pathogenicity. Despite this, the relative contribution of these virulence factors and other genetic changes to the pathogenicity of <i>E. faecalis</i> strains remain poorly understood. Here, we investigated whether specific genomic changes in the genome of <i>E. faecalis</i> isolates influence its pathogenicity-infection of hospitalized and nonhospitalized individuals and the propensity to cause extraintestinal infection and intestinal colonization. Our findings indicate that <i>E. faecalis</i> genetics partially influence the infection of hospitalized and nonhospitalized individuals and the propensity to cause extraintestinal infection, possibly due to gut-to-bloodstream translocation, highlighting the potential substantial role of host and environmental factors, including gut microbiota, on the opportunistic pathogenic lifestyle of this bacterium.

Item Type: Article
Uncontrolled Keywords: bacteria, genome-wide association study, infectious disease, microbial genomics
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 06 Feb 2024 11:11
Last Modified: 06 Feb 2024 11:11
DOI: 10.1128/spectrum.00201-23
Open Access URL: https://doi.org/10.1128/spectrum.00201-23
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3178484
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