The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: Protocol for school-age follow-up.

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Piper, Joseph D, Mazhanga, Clever, Mwapaura, Marian, Mapako, Gloria, Mapurisa, Idah, Mashedze, Tsitsi, Munyama, Eunice, Kuona, Maria, Mashiri, Thombizodwa, Sibanda, Kundai et al (show 26 more authors) , Matemavi, Dzidzai, Tichagwa, Monica, Nyoni, Soneni, Saidi, Asinje, Mangwende, Manasa, Chidhanguro, Dzivaidzo, Mpofu, Eddington, Tome, Joice, Mutasa, Batsirai, Chasekwa, Bernard, Smuk, Melanie, Smith, Laura E, Njovo, Handrea, Nyachowe, Chandiwana, Muchekeza, Mary, Mutasa, Kuda, Sauramba, Virginia, Langhaug, Lisa F, Tavengwa, Naume V, Gladstone, Melissa J ORCID: 0000-0002-2579-9301, Wells, Jonathan C, Allen, Elizabeth, Humphrey, Jean H, Ntozini, Robert, SHINE Follow-up team, and Prendergast, Andrew J (2023) The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: Protocol for school-age follow-up. Wellcome open research, 8. p. 306.

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Abstract

<b>Background</b>: There is a need for follow-up of early-life stunting intervention trials into childhood to determine their long-term impact. A holistic school-age assessment of health, growth, physical and cognitive function will help to comprehensively characterise the sustained effects of early-life interventions. <b>Methods:</b> The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe assessed the effects of improved infant and young child feeding (IYCF) and/or improved water, sanitation and hygiene (WASH) on stunting and anaemia at 18 months. Among children enrolled to SHINE, 1,275 have been followed up at 7-8 years of age (1,000 children who have not been exposed to HIV, 268 exposed to HIV antenatally who remain HIV negative and 7 HIV positive children). Children were assessed using the School-Age Health, Activity, Resilience, Anthropometry and Neurocognitive (SAHARAN) toolbox, to measure their growth, body composition, cognitive and physical function. In parallel, a caregiver questionnaire assessed household demographics, socioeconomic status, adversity, nurturing, caregiver support, food and water insecurity. A monthly morbidity questionnaire is currently being administered by community health workers to evaluate school-age rates of infection and healthcare-seeking. The impact of the SHINE IYCF and WASH interventions, the early-life 'exposome', maternal HIV, and contemporary exposures on each school-age outcome will be assessed. We will also undertake an exploratory factor analysis to generate new, simpler metrics for assessment of cognition (COG-SAHARAN), growth (GROW-SAHARAN) and combined growth, cognitive and physical function (SUB-SAHARAN). The SUB-SAHARAN toolbox will be used to conduct annual assessments within the SHINE cohort from ages 8-12 years. <b>Ethics and dissemination:</b> Approval was obtained from Medical Research Council of Zimbabwe (08/02/21) and registered with Pan-African Clinical Trials Registry (PACTR202201828512110, 24/01/22). Primary caregivers provided written informed consent and children written assent. Findings will be disseminated through community sensitisation, peer-reviewed journals and stakeholders including the Zimbabwean Ministry of Health and Child Care.

Item Type:	Article
Uncontrolled Keywords:	SHINE Follow-up team
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Feb 2024 11:11
Last Modified:	06 Feb 2024 11:11
DOI:	10.12688/wellcomeopenres.19463.1
Open Access URL:	https://doi.org/10.12688/wellcomeopenres.19463.1
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178491