Panebianco, Mariangela 
ORCID: 0000-0001-8956-5486, Marson, Anthony and Manohar, Radhika
(2023)
Quantitative Analysis of EEG Signal in Drug-Resistant Juvenile Myoclonic Epilepsy.
Quantitative Analysis of EEG Signal in Drug-Resistant Juvenile Myoclonic Epilepsy, 2 (1).
pp. 1-10.
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Abstract
Juvenile Myoclonic Epilepsy (JME) is a genetic generalised epilepsy syndromes characterized by myoclonic jerks mostly in the morning, tonic-clonic seizures and absence seizures. About 30% of people with JME continue to have seizures despite treatment with antiepileptic drugs. Quantitative EEG (qEEG) is a computer analysis of the electroencephalography. The aim of this study was to compare qualitative vs quantitative EEG, quantitatively analyse background EEG activity in two different physiological states and the correlation with cognitive performances in patients with refractory JME. Inclusion criteria were: drug-resistant JME and aged between 14 and 65 years. The recorded ambulatory EEG data was subjected to visual and quantitative analysis and chosed two samples of 20-60 second duration per patient, morning sample (MS) and evening sample (ES). Our study cohort consisted of 19 patients with refractory JME, 6 females and 13 males, with a mean age of 29.8 years. EEG visual analysis of background activity revealed inter-ictal abnormalities in all patients localized to left frontal region. When we compared dominant rhythm in standard EEG with dominant rhythm in qEEG we have found that is <50% observer agreement. Agreement occurred in samples dominated by increased amount of theta and beta in both visual and qEEG. With spectral analysis there was no statistically significant difference of global absolute power (AP) in all the bands between MS and ES groups; the same result was found using Z scores. We have found an increase in mean AP Z scores delta, theta and beta in MS group and theta and beta in ES group, which was more evident in left frontal region. In addition, an increase theta/alpha index > 1.50 is associated with a decrease in cognitive IQ scores.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | refractory juvenile mioclonic epilepsy, quantitative EEG, spectral analysis, psysiological states, ; cognitive scores |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Feb 2024 17:27 |
| Last Modified: | 06 Feb 2024 17:27 |
| DOI: | 10.59657/2992-9768.brs.23.004 |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178508 |
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