Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.

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Taquet, Maxime, Skorniewska, Zuzanna, Zetterberg, Henrik ORCID: 0000-0003-3930-4354, Geddes, John R, Mummery, Catherine J, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael ORCID: 0000-0002-7585-4743, Poinasamy, Krisnah et al (show 24 more authors) , Raman, Betty ORCID: 0000-0002-1239-9608, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish JC, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M, Harris, Victoria Claire, Houchen-Wolloff, Linzy, Mansoori, Parisa, Greening, Neil J, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Greenhalf, William ORCID: 0000-0002-1865-3195, Wain, Louise V, Brightling, Christopher E, Evans, Rachael E, Harrison, Paul J ORCID: 0000-0002-6719-1126, Koychev, Ivan ORCID: 0000-0001-6813-8493 and PHOSP-COVID Study Collaborative Group, (2024) Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury. Brain communications, 6 (1). fcad357-.

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Abstract

A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury.

Item Type:	Article
Uncontrolled Keywords:	PHOSP-COVID Study Collaborative Group
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	14 Feb 2024 11:18
Last Modified:	14 Feb 2024 11:19
DOI:	10.1093/braincomms/fcad357
Open Access URL:	https://doi.org/10.1093/braincomms/fcad357
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178646