Omar, Rawan, Saliba, Walaa, Khatib, Muhammad, Zheng, Youbin 
ORCID: 0000-0003-3905-8552, Pieters, Calvin, Oved, Hadas, Silberman, Eric, Zohar, Orr, Hu, Zhipeng, Kloper, Viki et al (show 5 more authors)
(2024)
Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring.
ACS sensors, 9 (1).
pp. 126-138.
Abstract
Cardiac monitoring after heart surgeries is crucial for health maintenance and detecting postoperative complications early. However, current methods like rigid implants have limitations, as they require performing second complex surgeries for removal, increasing infection and inflammation risks, thus prompting research for improved sensing monitoring technologies. Herein, we introduce a nanosensor platform that is biodegradable, biocompatible, and integrated with multifunctions, suitable for use as implants for cardiac monitoring. The device has two electrochemical biosensors for sensing lactic acid and pH as well as a pressure sensor and a chemiresistor array for detecting volatile organic compounds. Its biocompatibility with myocytes has been tested in vitro, and its biodegradability and sensing function have been proven with ex vivo experiments using a three-dimensional (3D)-printed heart model and 3D-printed cardiac tissue patches. Moreover, an artificial intelligence-based predictive model was designed to fuse sensor data for more precise health assessment, making it a suitable candidate for clinical use. This sensing platform promises impactful applications in the realm of cardiac patient care, laying the foundation for advanced life-saving developments.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Monitoring, Physiologic, Biosensing Techniques, Prostheses and Implants, Artificial Intelligence, Wearable Electronic Devices |
| Divisions: | Faculty of Science and Engineering > School of Electrical Engineering, Electronics and Computer Science |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Feb 2024 11:00 |
| Last Modified: | 20 Feb 2024 11:00 |
| DOI: | 10.1021/acssensors.3c01755 |
| Open Access URL: | https://doi.org/10.1021/acssensors.3c01755 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178798 |
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