Genome-Wide Differential Transcription of Long Noncoding RNAs in Psoriatic Skin.

Stacey, Valerie M and Kõks, Sulev (2023) Genome-Wide Differential Transcription of Long Noncoding RNAs in Psoriatic Skin. International journal of molecular sciences, 24 (22). p. 16344.

Access the full-text of this item by clicking on the Open Access link.

Official URL: http://dx.doi.org/10.3390/ijms242216344

Abstract

Long noncoding RNAs (lncRNAs) may contribute to the formation of psoriatic lesions. The present study's objective was to identify long lncRNA genes that are differentially expressed in patient samples of psoriasis through computational analysis techniques. By using previously published RNA sequencing data from psoriatic and healthy patients (n = 324), we analysed the differential expression of lncRNAs to determine transcripts of heightened expression. We computationally screened lncRNA transcripts as annotated by GENCODE across the human genome and compared transcription in psoriatic and healthy samples from two separate studies. We observed 54 differentially expressed genes as seen in two independent datasets collected from psoriasis and healthy patients. We also identified the differential expression of LINC01215 and LINC1206 associated with the cell cycle pathway and psoriasis pathogenesis. SH3PXD2A-AS1 was identified as a participant in the STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop. Both the SH3PXD2A-AS1 and CERNA2 genes have already been recognised as part of the IFN-γ signalling pathway regulation. Additionally, EPHA1-AS1, CYP4Z2P and SNHG12 gene upregulation have all been previously linked to inflammatory skin diseases. Differential expression of various lncRNAs affects the pathogenesis of psoriasis. Further characterisation of lncRNAs and their functions are important for developing our understanding of psoriasis.

Item Type:	Article
Uncontrolled Keywords:	Skin, Humans, Dermatitis, Psoriasis, Sequence Analysis, RNA, Gene Expression Regulation, Neoplastic, RNA, Long Noncoding
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	20 Feb 2024 11:18
Last Modified:	20 Feb 2024 11:18
DOI:	10.3390/ijms242216344
Open Access URL:	https://doi.org/10.3390/ijms242216344
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178811