Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response-a scoping review.

Dervenis, Nikolaos ORCID: 0000-0002-7269-2785, Dervenis, Panagiotis and Agorogiannis, Eleftherios (2024) Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response-a scoping review. BMJ open ophthalmology, 9 (1). e001516-e001516.

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Abstract

Age-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. At the same time, new challenges and unmet needs arose due to the limitations of the current therapeutic options. Neovascularisation development during the course of the disease has a complex pathogenetic mechanism, and several biomarkers and their association with treatment outcomes have been investigated. We reviewed the relevant literature about neovascularisation development and biomarkers related to response to treatment. Improving our knowledge on the field can improve patient outcomes and offer personalised care.

Item Type:	Article
Uncontrolled Keywords:	Humans, Macular Degeneration, Neovascularization, Pathologic, Angiogenesis Inhibitors, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	20 Feb 2024 11:22
Last Modified:	26 Feb 2024 08:16
DOI:	10.1136/bmjophth-2023-001516
Open Access URL:	https://bmjophth.bmj.com/content/9/1/e001516
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178814