Pre-Operative Malnutrition in Patients with Ovarian Cancer: What Are the Clinical Implications? Results of a Prospective Study.

Nasser, Sara, Bilir, Esra ORCID: 0000-0003-4499-6543, Derin, Xezal, Richter, Rolf, Grabowski, Jacek P, Ali, Paulina, Kulbe, Hagen, Chekerov, Radoslav, Braicu, Elena and Sehouli, Jalid (2024) Pre-Operative Malnutrition in Patients with Ovarian Cancer: What Are the Clinical Implications? Results of a Prospective Study. Cancers, 16 (3). p. 622.

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Official URL: http://dx.doi.org/10.3390/cancers16030622

Abstract

<h4>Background</h4>Malnutrition was associated with worse survival outcomes, impaired quality of life, and deteriorated performance status across various cancer types. We aimed to identify risk factors for malnutrition in patients with epithelial ovarian cancer (EOC) and impact on survival.<h4>Methods</h4>In our prospective observational monocentric study, we included the patients with primary and recurrent EOC, tubal or peritoneal cancer conducted. We assessed serum laboratory parameters, body mass index, nutritional risk index, nutritional risk screening score (NRS-2002), and bio-electrical impedance analysis.<h4>Results</h4>We recruited a total of 152 patients. Patients > 65 years-old, with ascites of >500 mL, or with platinum-resistant EOC showed statistically significant increased risk of malnutrition when evaluated using NRS-2002 (<i>p</i>-values= 0.014, 0.001, and 0.007, respectively). NRS-2002 < 3 was an independent predictive factor for complete tumor resectability (<i>p</i> = 0.009). The patients with NRS-2002 ≥ 3 had a median overall survival (OS) of seven months (95% CI = 0-24 months), as compared to the patients with NRS-2002 < 3, where median OS was forty-six months (<i>p</i> = 0.001). A phase angle (PhAα) ≤ 4.5 was the strongest predictor of OS.<h4>Conclusions</h4>In our study, we found malnutrition to be an independent predictor of incomplete cytoreduction and independent prognostic factor for poor OS. Preoperative nutritional assessment is an effective tool in the identification of high-risk EOC groups characterized by poor clinical outcome.

Item Type:	Article
Uncontrolled Keywords:	malnutrition, nutrition, nutritional risk screening score, ovarian cancer, overall survival, phase angle, progression-free survival
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	20 Feb 2024 11:23
Last Modified:	26 Feb 2024 08:18
DOI:	10.3390/cancers16030622
Open Access URL:	https://doi.org/10.3390/cancers16030622
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178816