Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart's Disease

Chaemsaithong, Piya, Luewan, Suchaya, Taweevisit, Mana, Chiangjong, Wararat, Pongchaikul, Pisut ORCID: 0000-0001-8757-3554, Thorner, Paul Scott, Tongsong, Theera and Chutipongtanate, Somchai (2023) Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (6). 5658-.

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Abstract

Extracellular vesicles (EVs) are nano-scaled vesicles released from all cell types into extracellular fluids and specifically contain signature molecules of the original cells and tissues, including the placenta. Placenta-derived EVs can be detected in maternal circulation at as early as six weeks of gestation, and their release can be triggered by the oxygen level and glucose concentration. Placental-associated complications such as preeclampsia, fetal growth restriction, and gestational diabetes have alterations in placenta-derived EVs in maternal plasma, and this can be used as a liquid biopsy for the diagnosis, prediction, and monitoring of such pregnancy complications. Alpha-thalassemia major ("homozygous alpha-thalassemia-1") or hemoglobin Bart's disease is the most severe form of thalassemia disease, and this condition is lethal for the fetus. Women with Bart's hydrops fetalis demonstrate signs of placental hypoxia and placentomegaly, thereby placenta-derived EVs provide an opportunity for a non-invasive liquid biopsy of this lethal condition. In this article, we introduced clinical features and current diagnostic markers of Bart's hydrops fetalis, extensively summarize the characteristics and biology of placenta-derived EVs, and discuss the challenges and opportunities of placenta-derived EVs as part of diagnostic tests for placental complications focusing on Bart's hydrop fetalis.

Item Type:	Article
Uncontrolled Keywords:	biomarkers, diagnosis, exosomes, hemoglobinopathy, hydrop fetalis, liquid biopsy, placental hypoxia, thalassemia
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	28 Feb 2024 10:28
Last Modified:	28 Feb 2024 10:28
DOI:	10.3390/ijms24065658
Open Access URL:	https://doi.org/10.3390/ijms24065658
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3178942