Wu, Xuemei 
ORCID: 0000-0003-3442-324X, Chen, Si ORCID: 0000-0002-6129-2989, Chen, Ping, Zhang, Han, Zhang, Liying, Wang, Panjun, Li, Bingzong, Rong, Rong, Wang, Yiting, Lang, Xingping et al (show 3 more authors)
(2023)
<i>IGH::CD274 (PD-L1)</i> rearrangement in diffuse large B cell lymphoma and its therapeutic implication.
EJHaem, 4 (2).
pp. 442-445.
Abstract
Diffuse large B cell lymphoma (DLBCL) expresses abundant programmed death ligand 1 (PD-L1), which shields tumor cells from immune attacks through the PD-L1/PD-1 signaling axis. The mechanism of PD-L1 overexpression includes the deletion of the 3'end of <i>PD-L1</i>, which increases its mRNA stability, and the gain or amplification of <i>PD-L1</i>. Previous studies found two cases of DLBCL carrying an <i>IGH::PD-L1</i> by whole genome sequencing. We describe two more such cases by a targeted DNA next-generation sequencing (NGS) capable of detecting <i>IGH</i> rearrangements, leading to <i>PD-L1</i> overexpression. DLBCL with PD-L1 overexpression is often resistant to R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone). Our patients responded to a combination of R-CHOP and a PD-1 inhibitor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DLBCL, IGH, PDL1 |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 28 Feb 2024 10:58 |
| Last Modified: | 28 Feb 2024 10:58 |
| DOI: | 10.1002/jha2.693 |
| Open Access URL: | https://doi.org/10.1002/jha2.693 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178952 |
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