Schwenke, Johannes M 
ORCID: 0009-0006-9795-6181, Thorball, Christian W, Schoepf, Isabella C, Ryom, Lene, Hasse, Barbara, Lamy, Olivier, Calmy, Alexandra, Wandeler, Gilles, Marzolini, Catia ORCID: 0000-0002-2312-7050, Kahlert, Christian R ORCID: 0000-0002-0784-3276 et al (show 8 more authors)
(2023)
Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study.
The Journal of infectious diseases, 228 (6).
pp. 742-750.
Abstract
<h4>Background</h4>Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH.<h4>Methods</h4>Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements.<h4>Results</h4>We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9).<h4>Conclusions</h4>In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Swiss HIV Cohort Study, Humans, HIV, HIV Infections, Bone Diseases, Metabolic, Osteoporosis, Risk Factors, Cohort Studies, Bone Density, Middle Aged, Switzerland, Female, Male, Tenofovir |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 29 Feb 2024 09:20 |
| Last Modified: | 29 Feb 2024 09:20 |
| DOI: | 10.1093/infdis/jiad179 |
| Open Access URL: | https://doi.org/10.1093/infdis/jiad179 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178984 |
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