Thoueille, Paul, Alves Saldanha, Susana, Schaller, Fabian, Munting, Aline, Cavassini, Matthias, Braun, Dominique, Günthard, Huldrych F, Kusejko, Katharina, Surial, Bernard, Furrer, Hansjakob et al (show 11 more authors)
(2022)
Real-Life Therapeutic Concentration Monitoring of Long-Acting Cabotegravir and Rilpivirine: Preliminary Results of an Ongoing Prospective Observational Study in Switzerland.
Pharmaceutics, 14 (8).
p. 1588.
Abstract
SHCS#879 is an ongoing Switzerland-wide multicenter observational study conducted within the Swiss HIV Cohort Study (SHCS) for the prospective follow-up of people living with HIV (PLWH) receiving long-acting injectable cabotegravir-rilpivirine (LAI-CAB/RPV). All adults under LAI-CAB/RPV and part of SHCS are enrolled in the project. The study addresses an integrated strategy of treatment monitoring outside the stringent frame of controlled clinical trials, based on relevant patient characteristics, clinical factors, potential drug-drug interactions, and measurement of circulating blood concentrations. So far, 91 blood samples from 46 PLWH have been collected. Most individuals are less than 50 years old, with relatively few comorbidities and comedications. The observed concentrations are globally in accordance with the available values reported in the randomized clinical trials. Yet, low RPV concentrations not exceeding twice the reported protein-adjusted 90% inhibitory concentration have been observed. Data available at present confirm a considerable between-patient variability overall. Based on the growing amount of PK data accumulated during this ongoing study, population pharmacokinetic analysis will characterize individual concentration-time profiles of LAI-CAB/RPV along with their variability in a real-life setting and their association with treatment response and tolerability, thus bringing key data for therapeutic monitoring and precision dosage adjustment of this novel long-acting therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cabotegravir, long-acting antiretroviral therapy, pharmacokinetic simulation, pharmacokinetics, population pharmacokinetic modeling, rilpivirine, therapeutic drug monitoring |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 29 Feb 2024 09:20 |
| Last Modified: | 29 Feb 2024 09:20 |
| DOI: | 10.3390/pharmaceutics14081588 |
| Open Access URL: | https://doi.org/10.3390/pharmaceutics14081588 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178996 |
Dimensions
Dimensions
