Relevance of vein wall thickness in Behcet's disease: A systematic review and meta-analysis.

Merashli, Mira, Bucci, Tommaso ORCID: 0000-0003-2895-6234, Delgado-Alves, Jose ORCID: 0000-0002-5216-4125 and Ames, Paul RJ (2023) Relevance of vein wall thickness in Behcet's disease: A systematic review and meta-analysis. Autoimmunity reviews, 23 (2). p. 103487.

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Official URL: http://dx.doi.org/10.1016/j.autrev.2023.103487

Abstract

<h4>Objectives</h4>To perform a meta-analysis on articles evaluating the common femoral vein wall thickness (VWT) in Behcet's disease and its possible clinical, laboratory and treatment correlates (BD).<h4>Methods</h4>Systematic search of EMBASE and PubMed databases from inception to October 2023; we employed random effect meta-analyses for continuous outcomes.<h4>Results</h4>The meta-analysis included 9 case-control and 1 cohort study: the VWT was greater in BD (n = 650) than in controls (n = 396) (p < 0.0001) with wide heterogeneity (I<sup>2</sup> = 94.4%); a sensitivity analysis that included mean age of BD participants, gender, disease duration and activity, C-reactive protein, smoking status, immune-suppressive and anti-inflammatory medication, revealed that the heterogeneity variance was partly explained by age (p < 0.0001), male gender (p = 0.03), disease duration (p < 0.0001) and smoking (p = 0.06). The VWT was greater in BD with thrombotic/vascular (n = 189) than in non-thrombotic/vascular BD (n = 140) (p = 0.006) with no heterogeneity.<h4>Conclusion</h4>VWT is greater in BD than controls: age, male gender, disease duration and smoking relate to VWT that was greater in BD patients with a history of thrombotic/vascular disease. Prospective studies are required to assess whether VWT may be considered a vascular marker of disease activity.

Item Type:	Article
Uncontrolled Keywords:	Behcet's disease, Venous wall thickness
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Mar 2024 08:14
Last Modified:	01 Mar 2024 08:14
DOI:	10.1016/j.autrev.2023.103487
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179010