Mazzotta, Cosimo, Stojanovic, Aleksandar, Romano, Vito 
ORCID: 0000-0002-5148-7643, Addabbo, Giuseppe, Borroni, Davide, Balamoun, Ashraf Armia and Ferrise, Marco
(2024)
Ray-Tracing Transepithelial Excimer Laser Central Corneal Remodeling Plus Pachymetry-Guided Accelerated Corneal Crosslinking for Keratoconus.
Cornea, 43 (3).
pp. 285-294.
Abstract
<h4>Purpose</h4>The aim of this study was to report the 12 to 96 months results of a tissue-preservation algorithm based on ray-tracing-guided transepithelial excimer laser central corneal ablation (RT t-PRK) combined with individualized pachymetry-guided accelerated crosslinking (M nomogram ACXL) in young adult patients with stable keratoconus (KC).<h4>Methods</h4>This was a prospective interventional study including 38 eyes of 38 young adult patients (stage II KC) with a mean age of 35 years (range 26-46 years) who underwent simultaneous RT with t-PRK plus pachymetry-based ACXL in the worst eye. The treatments were performed using the iViS Suite iRES Excimer Laser (Ligi, Taranto, Italy). Ray-tracing-guided treatments were planned using the customized interactive programmed transepithelial ablation (CIPTA) 2 web software and diagnostic data were assessed by the Precisio 2 tomographer (Ligi, Taranto, Italy) and Sirius tomographer (C.S.O., Florence, Italy). The main outcome measures included uncorrected distance visual acuity, best spectacle-corrected visual acuity, Kmax, high-order aberrations, minimum corneal thickness, and posterior elevation, with a mean follow-up of 52 months (range 12-96 m).<h4>Results</h4>The mean UDVA improved + 3.5 ±1.28 Snellen lines (SL); 38% gained ≥ 4 ±1.34 SLs, 35% ≥ 3 ±1.21 SLs, 22% ≥ 2 ±1.12 SLs, and 5% ≥ 1 ±0.75 SLs. The mean best spectacle-corrected visual acuity increased by + 4.3 ±1.3 SL. Sixty-eight percent gained ≥ 4 ±0.88 SLs and 30% ≥ 3 ±0.78 SL. No SLs were lost.<h4>Conclusions</h4>RT t-PRK plus ACXL significantly improved the quality of vision in patients with KC, preventing overcorrection and minimizing tissue consumption.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cornea, Humans, Keratoconus, Photosensitizing Agents, Cross-Linking Reagents, Corneal Topography, Prospective Studies, Adult, Middle Aged, Photorefractive Keratectomy, Lasers, Excimer, Young Adult |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Mar 2024 09:24 |
| Last Modified: | 01 Mar 2024 09:24 |
| DOI: | 10.1097/ico.0000000000003380 |
| Open Access URL: | http://10.0.4.73/ICO.0000000000003380 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179020 |
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