Mechanotransduction through protein stretching.

Guo, Yanyu, Yan, Jie and Goult, Benjamin T ORCID: 0000-0002-3438-2807 (2024) Mechanotransduction through protein stretching. Current opinion in cell biology, 87. p. 102327.

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Abstract

Cells sense and respond to subtle changes in their physicality, and via a myriad of different mechanosensitive processes, convert these physical cues into chemical and biochemical signals. This process, called mechanotransduction, is possible due to a highly sophisticated machinery within cells. One mechanism by which this can occur is via the stretching of mechanosensitive proteins. Stretching proteins that contain force-dependent regions results in altered geometry and dimensions of the connections, as well as differential spatial organization of signals bound to the stretched protein. The purpose of this mini-review is to discuss some of the intense recent activity in this area of mechanobiology that strives to understand how protein stretching can influence signaling outputs and cellular responses.

Item Type:	Article
Uncontrolled Keywords:	Signal Transduction, Mechanotransduction, Cellular
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	04 Mar 2024 09:26
Last Modified:	02 Apr 2024 09:31
DOI:	10.1016/j.ceb.2024.102327
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179045