Cunningham-Oakes, Edward 
ORCID: 0000-0003-0260-5508, Pilgrim, Jack ORCID: 0000-0002-2941-1482, Darby, Alistair ORCID: 0000-0002-3786-6209, Appleton, Charlotte, Jewell, Chris, Rowlingson, Barry, Cuartero, Carmen Tamayo, Newton, Richard, Sánchez-Vizcaíno, Fernando ORCID: 0000-0002-1655-8290, Fins, Ivo Salgueiro et al (show 9 more authors)
(2022)
Emerging variants of canine enteric coronavirus associated with seasonal outbreaks of severe canine gastroenteric disease.
[Preprint]
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Abstract
Canine enteric coronavirus (CECoV) variants have an emerging role in severe outbreaks of canine gastroenteritis. Here we used syndromic health data from a sentinel network of UK veterinary practices to identify an outbreak of severe canine gastroenteritis. Affected dogs frequently presented with vomiting, diarrhoea and inappetence. Data from sentinel diagnostic laboratories showed similar seasonal increases in CECoV diagnosis. Membrane glycoprotein (M) gene sequence analysis implied wide geographical circulation of a new CECoV variant. Whole genome sequencing suggested the main circulating 2022 variant was most closely related to one previously identified in 2020 with additional spike gene recombination; all variants were unrelated to CECoV-like viruses recently associated with human respiratory disease. Identifying factors that drive population-level evolution, and its implications for host protection and virulence, will be important to understand the emerging role of CECoV variants in canine and human health, and may act as a model for coronavirus population adaptation more widely.
| Item Type: | Preprint |
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| Uncontrolled Keywords: | Infectious Diseases, Biodefense, Digestive Diseases, Genetics, Pneumonia & Influenza, Emerging Infectious Diseases, Foodborne Illness, Vaccine Related, Prevention, 2.1 Biological and endogenous factors, 2 Aetiology, Infection, 3 Good Health and Well Being |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Research and Impact Directorate |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 Mar 2024 09:20 |
| Last Modified: | 14 Mar 2024 18:09 |
| DOI: | 10.1101/2022.10.03.510536 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179077 |
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