Cannabis and cannabinoids in dermatology: protocol for a systematic review and meta-analysis of quantitative outcomes.

Sermsaksasithorn, Pim, Nopsopon, Tanawin, Samuthpongtorn, Chatpol, Chotirosniramit, Korn and Pongpirul, Krit ORCID: 0000-0003-3818-9761 (2023) Cannabis and cannabinoids in dermatology: protocol for a systematic review and meta-analysis of quantitative outcomes. BMJ open, 13 (9). e075007-e075007.

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Abstract

<h4>Introduction</h4>Following the discovery of various effects on skin function by modifying endocannabinoid systems, multiple preclinical studies have revealed the promise of cannabis and cannabinoids in the treatment of a variety of skin diseases. However, its clinical efficacy is still debated.<h4>Methods and analysis</h4>The protocol has been prepared using the Preferred Items for Systematic Review and Meta-analysis Protocols guidelines. A systematic search will be conducted using PubMed, EMBASE, SCOPUS, the Cochrane Central Register of Controlled Trials and Web of Science. We will include randomised controlled trials and observational studies investigating alterations to dermatological characteristics following administration of cannabis and cannabinoids for dermatological diseases and disorders. The two reviewers will perform both the title and abstract and full-text screenings. The Cochrane Risk-of-Bias 2 and ROBINS-1 tools will be used to evaluate the risk of bias. If a group of comparable studies for each quantitative outcome can be discovered, we will conduct a random effects meta-analysis. We will investigate heterogeneity using a combination of visual inspection of the forest plot, the Cochran's Q test and Higgins' test [I2]. Sensitivity analyses will be performed to assess the statistical robustness of the primary outcome. To evaluate a publication bias, the Egger's regression asymmetry test and funnel plots will be considered.<h4>Ethics and dissemination</h4>This study does not require ethical approval because no original data will be collected. The findings will be presented at conferences and published in peer-reviewed journals.<h4>Prospero registration number</h4>CRD42023397189.

Item Type:	Article
Uncontrolled Keywords:	Humans, Cannabis, Cannabinoids, Dermatology, Meta-Analysis as Topic, Cannabinoid Receptor Agonists, Systematic Reviews as Topic
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Mar 2024 10:27
Last Modified:	06 Mar 2024 10:27
DOI:	10.1136/bmjopen-2023-075007
Open Access URL:	https://bmjopen.bmj.com/content/13/9/e075007
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179161