Prasithsirikul, Wisit, Nopsopon, Tanawin, Phutrakool, Phanupong, Suwanwattana, Pawita, Kantagowit, Piyawat, Pongpirul, Wannarat, Jongkaewwattana, Anan and Pongpirul, Krit 
ORCID: 0000-0003-3818-9761
(2022)
ChAdOx1 nCoV-19 Immunogenicity and Immunological Response Following COVID-19 Infection in Patients Receiving Maintenance Hemodialysis.
Vaccines, 10 (6).
p. 959.
Abstract
Patients with end-stage renal disease (ESRD) receiving hemodialysis (HD) were found to have a decreased immune response following mRNA COVID-19 immunization. ChAdOx1 nCoV-19 was a promising COVID-19 vaccine that performed well in the general population, but the evidence on immunogenicity in ESRD with HD patients was limited. Moreover, the immunological response to COVID-19 infection was inconclusive in patients with ESRD and HD. The aim of this study was to investigate the immunogenicity of ChAdOx1 nCoV-19 vaccination and the immunological response after COVID-19 infection in ESRD patients with HD. The blood samples were obtained at baseline, 1-month, and 3-month follow-up after each shot or recovery. All participants were measured for anti-spike IgG by the ELISA method, using Euroimmun. This study found a significant increase in anti-spike IgG after 1 month of two-shot ChAdOx1 nCoV-19 vaccination, followed by a significant decrease after 3 months. On the other hand, the anti-spike IgG was maintained in the post-recovery group. There was no significant difference in the change of anti-spike IgG between the one-shot ChAdOx1 nCoV-19-vaccinated and post-recovery groups for both 1-month and 3-month follow-ups. The seroconversion rate for the vaccinated group was 60.32% at 1 month after one-shot vaccination and slightly dropped to 58.73% at the 3-month follow-up, then was 92.06% at 1 month after two-shot vaccination and reduced to 82.26% at the 3-month follow-up. For the recovered group, the seroconversion rate was 95.65% at 1 month post-recovery and 92.50% at 3-month follow-up. This study demonstrated the immunogenicity of two-dose ChAdOx1 nCoV-19 in ESRD patients with HD for humoral immunity. After COVID-19 infection, the humoral immune response was strong and could be maintained for at least three months.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19, ChAdOx1 nCoV-19, ESRD, SARS-CoV-2, hemodialysis, immunogenicity, post-infection, vaccines |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Mar 2024 10:28 |
| Last Modified: | 06 Mar 2024 10:28 |
| DOI: | 10.3390/vaccines10060959 |
| Open Access URL: | https://doi.org/10.3390/vaccines10060959 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179162 |
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