Childhood TB sequel: evaluating respiratory function after treatment for pulmonary tuberculosis in a prospective cohort of Gambian children - a study protocol.

Nkereuwem, Esin, Agbla, Schadrac, Jatta, Muhammed Lamin, Masterton, Uma, Owolabi, Olumuyiwa, Edem, Victory Fabian, Kampmann, Beate and Togun, Toyin (2023) Childhood TB sequel: evaluating respiratory function after treatment for pulmonary tuberculosis in a prospective cohort of Gambian children - a study protocol. BMC pulmonary medicine, 23 (1). p. 387.

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Official URL: http://dx.doi.org/10.1186/s12890-023-02659-2

Abstract

<h4>Background</h4>1.2 million children under 15 years are estimated to have developed tuberculosis (TB) in 2021. 85% of paediatric patients achieve successful treatment outcomes if treated for the first episode of TB. However, despite so-called successful treatment, TB leaves many survivors with permanently destroyed or damaged lungs. Data from prospective paediatric cohorts to establish the burden and evolution of post-TB lung disease (PTLD) are still absent. The Childhood TB Sequel study aims to describe respiratory consequences associated with pulmonary TB in Gambian children, describe the evolution of these sequelae, and determine associated epidemiological risk factors.<h4>Methods</h4>We aim to recruit up to 80 subjects aged 19 years and below who have recently completed treatment for pulmonary TB. Recruitment started in April 2022 and is expected to continue until June 2024. Clinical assessment, chest X-ray, and comprehensive lung function assessment are carried out at treatment completion and again six and 12 months later.<h4>Discussion</h4>The Childhood TB Sequel study will address existing research gaps to enhance our knowledge and understanding of the burden of PTLD in Gambian children. The study will also contribute to formulating a plan for post-TB evaluation and long-term follow-up strategies.<h4>Trial registration</h4>ClinicalTrials.gov: NCT05325125, April 13, 2022.

Item Type:	Article
Uncontrolled Keywords:	Humans, Tuberculosis, Tuberculosis, Pulmonary, Prospective Studies, Respiration, Child, Gambia
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	06 Mar 2024 10:29
Last Modified:	06 Mar 2024 10:29
DOI:	10.1186/s12890-023-02659-2
Open Access URL:	https://doi.org/10.1186/s12890-023-02659-2
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179163