Rhee, Tae-Min, Choi, JungMin, Choi, Eue-Keun, Lee, Kyung-Yeon, Ahn, Hyo-Jeong, Kwon, Soonil, Lee, So-Ryoung, Oh, Seil and Lip, Gregory YH 
ORCID: 0000-0002-7566-1626
(2024)
Neuroticism and the Risk of Atrial Fibrillation: An Observational Epidemiologic and Mendelian Randomization Study.
JACC. Asia, 4 (2).
pp. 138-147.
Abstract
<h4>Background</h4>The association between neuroticism and atrial fibrillation (AF) remains unknown.<h4>Objectives</h4>This study aimed to assess the epidemiological and causal relationships between neuroticism and AF.<h4>Methods</h4>Individuals without AF history were selected From the UK Biobank nationwide prospective cohort study. Participants were divided into 2 groups (high and low) based on the median summary score from a self-questionnaire of 12 neurotic behavior domains. The 10-year AF risk was compared between the neuroticism score groups using inverse probability of treatment weighting. The causal relationship between neuroticism and AF was evaluated using a 2-sample summary-level Mendelian randomization with the inverse variance-weighted method.<h4>Results</h4>Of 394,834 participants (mean age 56.3 ± 8.1 years, 45.9% male), AF occurred in 23,509 (6.0%) during a 10-year follow-up. The risk of incident AF significantly increased in the high neuroticism score group (score ≥4) (inverse probability of treatment weighting-adjusted HR: 1.05; 95% CI: 1.02-1.09; <i>P =</i> 0.005) compared with the low neuroticism group. In the subgroup analysis, younger age, lower body mass index, or nonsmoker/ex-smoker participants were particularly susceptible to increased AF risk due to high neuroticism scores. A Mendelian randomization analysis showed a significant causal relationship between an increase in neuroticism score and increased risk of AF (OR by inverse variance-weighted method 1.06; 95% CI: 1.02-1.11; <i>P =</i> 0.007) without evidence of reverse causality.<h4>Conclusions</h4>There was a significant longitudinal and causal relationship between neuroticism and AF. An integrated care including active mental health screening and management may benefit in high-risk populations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Mendelian randomization, atrial fibrillation, neuroticism, outcome |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Mar 2024 10:51 |
| Last Modified: | 06 Mar 2024 10:51 |
| DOI: | 10.1016/j.jacasi.2023.09.010 |
| Open Access URL: | https://doi.org/10.1016/j.jacasi.2023.09.010 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179180 |
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