Talin in mechanotransduction and mechanomemory at a glance.

Goult, Benjamin T ORCID: 0000-0002-3438-2807, Brown, Nicholas H and Schwartz, Martin A (2021) Talin in mechanotransduction and mechanomemory at a glance. Journal of cell science, 134 (20). jcs258749-.

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Official URL: http://dx.doi.org/10.1242/jcs.258749

Abstract

Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible neck region and a C-terminal rod domain made of 13 helical bundles. The head domain binds integrin β-subunit cytoplasmic tails, which triggers integrin conformational activation to increase affinity for extracellular matrix proteins. The rod domain links to actin filaments inside the cell to transmit mechanical loads and serves as a mechanosensitive signalling hub for the recruitment of many other proteins. The α-helical bundles function as force-dependent switches - proteins that interact with folded bundles are displaced when force induces unfolding, exposing previously cryptic binding sites for other ligands. This leads to the notion of a talin code. In this Cell Science at a Glance article and the accompanying poster, we propose that the multiple switches within the talin rod function to process and store time- and force-dependent mechanical and chemical information.

Item Type:	Article
Uncontrolled Keywords:	Talin, Integrins, Signal Transduction, Mechanotransduction, Cellular, Binding Sites, Protein Binding
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	13 Mar 2024 10:05
Last Modified:	13 Mar 2024 10:05
DOI:	10.1242/jcs.258749
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179292