The tale of two talins - two isoforms to fine-tune integrin signalling.

Gough, Rosemarie E ORCID: 0000-0002-5587-4683 and Goult, Benjamin T ORCID: 0000-0002-3438-2807 (2018) The tale of two talins - two isoforms to fine-tune integrin signalling. FEBS letters, 592 (12). pp. 2108-2125.

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Abstract

Talins are cytoplasmic adapter proteins essential for integrin-mediated cell adhesion to the extracellular matrix. Talins control the activation state of integrins, link integrins to cytoskeletal actin, recruit numerous signalling molecules that mediate integrin signalling and coordinate recruitment of microtubules to adhesion sites via interaction with KANK (kidney ankyrin repeat-containing) proteins. Vertebrates have two talin genes, TLN1 and TLN2. Although talin1 and talin2 share 76% protein sequence identity (88% similarity), they are not functionally redundant, and the differences between the two isoforms are not fully understood. In this Review, we focus on the similarities and differences between the two talins in terms of structure, biochemistry and function, which hint at subtle differences in fine-tuning adhesion signalling.

Item Type:	Article
Uncontrolled Keywords:	Cell Membrane, Animals, Humans, Talin, Integrins, Protein Isoforms, Signal Transduction, Protein Conformation, Sequence Homology, Amino Acid, Models, Molecular
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	13 Mar 2024 09:56
Last Modified:	13 Mar 2024 09:56
DOI:	10.1002/1873-3468.13081
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179319