Yan, Jie, Yao, Mingxi 
ORCID: 0000-0002-3905-8475, Goult, Benjamin T ORCID: 0000-0002-3438-2807 and Sheetz, Michael P
(2015)
Talin Dependent Mechanosensitivity of Cell Focal Adhesions.
Cellular and molecular bioengineering, 8 (1).
pp. 151-159.
|
PDF
2015_Yan_CAMB.pdf - Open Access published version Download (1MB) | Preview |
Abstract
A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing proteins and converted into signals that direct cells to adapt to the external environment. A key function of cell adhesion to the extracellular matrix (ECM) is to transduce mechanical forces between cells and their extracellular environment. Talin, a cytoplasmic adapter essential for integrin-mediated adhesion to the ECM, links the actin cytoskeleton to integrin at the plasma membrane. Here, we review recent progress in the understanding of talin-dependent mechanosensing revealed by stretching single talin molecules. Rapid progress in single-molecule force manipulation technologies has made it possible to directly study the impact of mechanical force on talin's conformations and its interactions with other signaling proteins. We also provide our views on how findings from such studies may bring new insights into understanding the principles of mechanobiology on a broader scale, and how such fundamental knowledge may be harnessed for mechanopharmacology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cell adhesion, Magnetic tweezers, Mechanosensing, Talin, Vinculin |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Mar 2024 09:40 |
| Last Modified: | 13 Mar 2024 09:40 |
| DOI: | 10.1007/s12195-014-0364-5 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179343 |
Dimensions
Dimensions
