The left posterior angular gyrus is engaged by autobiographical recall not object-semantics, or event-semantics: Evidence from contrastive propositional speech production

Humphreys, Gina F, Halai, Ajay D, Branzi, Francesca M ORCID: 0000-0002-3780-9693 and Lambon Ralph, Matthew A (2024) The left posterior angular gyrus is engaged by autobiographical recall not object-semantics, or event-semantics: Evidence from contrastive propositional speech production. Imaging Neuroscience.

PDF
Humphreys_2024.pdf - Author Accepted Manuscript
Download (5MB) | Preview

Official URL: http://dx.doi.org/10.1162/imag_a_00116

Abstract

<jats:title>Abstract</jats:title> <jats:p>The angular gyrus (AG) has been implicated in a myriad of cognitive functions. Using the previously under-studied naturalistic task of propositional speech production, we investigated the engagement of the left posterior AG (pAG) by three forms of memory: 1) episodic/autobiographical memory, 2) object semantic-memory, and 3) event-semantic knowledge. We conducted an ALE meta-analysis, followed by an fMRI study. The meta-analysis showed that pAG is only engaged as part of the propositional speech network when the task carries an autobiographical component. This finding was supported by the fMRI results, which also showed that: 1) pAG was positively engaged during autobiographical memory retrieval; 2) pAG was strongly deactivated for definitions of object semantics and non-propositional speech; 3) pAG activation increased with the degree to which the event descriptions relied on autobiographical information; 4) critically, the pAG showed a different pattern to known semantic representation regions (e.g., ventral anterior temporal lobe (vATL)) thereby providing clear evidence that the pAG is not acting as a semantic hub. Instead, the pAG activation profile directly mirrored that found in the wider autobiographical retrieval network. We propose that information stored elsewhere in the episodic system is temporally buffered online in the pAG during autobiographical retrieval/memory construction.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	Behavioral and Social Science, Neurodegenerative, Basic Behavioral and Social Science, Clinical Research, Mental Health, Neurosciences
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	18 Mar 2024 16:26
Last Modified:	18 Mar 2024 16:26
DOI:	10.1162/imag_a_00116
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179511