Thiamine fortification strategies in low- and middle-income settings: a review

Whitfield, Kyly C, Smith, Taryn J ORCID: 0000-0001-9543-6461, Rohner, Fabian, Wieringa, Frank T and Green, Tim J (2021) Thiamine fortification strategies in low- and middle-income settings: a review. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1498 (1). pp. 29-45.

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Abstract

Thiamine (vitamin B₁ ) is an essential micronutrient in energy metabolism and cognitive and neurological health. Thiamine deficiency disorders (TDDs) have a range of clinical presentations that result in various morbidities and can be fatal if not promptly recognized and treated, especially in infants. To intervene, thiamine intakes by breastfeeding mothers and others at risk of thiamine deficiency should be increased to ensure adequate thiamine intake. Although thiamine fortification programs have a long history in high-income countries, there are few mandatory fortification programs to address TDDs in low- and middle-income countries (LMICs), particularly in the regions of greatest concern, South and Southeast Asia. This review highlights essential aspects for consideration in the development of a mandatory fortification program in LMICs, including an overview of the data required to model fortification dosing schemes, available thiamine fortificants, and potential fortification vehicles, as well as identifies current knowledge gaps.

Item Type:	Article
Uncontrolled Keywords:	thiamine, vitamin B-1, fortification, enrichment, thiamine deficiency disorders
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	18 Mar 2024 15:57
Last Modified:	18 Mar 2024 15:57
DOI:	10.1111/nyas.14565
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179538