Oguti, Blanche 
ORCID: 0000-0001-9087-9992, Gibani, Malick, Darlow, Christopher ORCID: 0000-0002-5400-3413, Waddington, Claire S, Jin, Celina, Plested, Emma, Campbell, Danielle ORCID: 0000-0001-5794-8036, Jones, Claire, Darton, Tom C and Pollard, Andrew J ORCID: 0000-0001-7361-719X
(2019)
Factors influencing participation in controlled human infection models: a pooled analysis from six enteric fever studies.
Wellcome Open Research, 4.
p. 153.
Abstract
<ns4:p><ns4:bold>Background:</ns4:bold> Enteric fever is an acute febrile-illness caused by infection with the human-restricted <ns4:italic>Salmonella</ns4:italic> serovars Typhi and Paratyphi. Controlled human infection models (CHIM) of <ns4:italic>S</ns4:italic>. Typhi and Paratyphi infection are used to accelerate vaccine development and to better understand host-pathogen interactions. The primary motivations for participants to take part in these studies are unknown. We studied participant motivations, attitudes and the factors influencing CHIM study participation.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Participant surveys were nested in six enteric fever CHIM studies conducted at a single centre in Oxford, UK, between 2011 and 2017. All eligible participants received one invitation to complete an anonymous, self-administered paper or online survey on either day 28 or 60 after challenge. A descriptive analysis was performed on these pooled data. All studies were included, to minimize selection bias.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Survey response rates varied from 33.0%-86.1%, yielding 201 participants. In the cohort, 113/198(57.0%) were educated to bachelor’s level, 61.6% were employed, 30.3% were students and 4.6% were unemployed. The most commonly cited motivations for CHIM study participation were a desire to contribute to the progression of medicine (170/201; 84.6%); the prospect of financial reimbursement (166/201; 82.6%) and curiosity about clinical trials (117/201; 57.2%). The majority of respondents (139/197; 70.6%) reported that most people advised them against participation.</ns4:p><ns4:p> <ns4:bold>Conclusion:</ns4:bold> Motivation to participate in a CHIM study was multi-factorial and heavily influenced by internal drivers beyond monetary reimbursement alone. High educational attainment and employment may be protective factors against financial inducement; however, further research is needed, particularly with CHIM studies expanding to low-income and middle-income countries.</ns4:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Infectious Diseases, Basic Behavioral and Social Science, Clinical Research, Rare Diseases, Behavioral and Social Science, 3 Good Health and Well Being |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 Mar 2024 09:44 |
| Last Modified: | 12 Apr 2024 12:50 |
| DOI: | 10.12688/wellcomeopenres.15469.1 |
| Open Access URL: | https://wellcomeopenresearch.org/articles/4-153 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179626 |
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