Qu, ZhanXin, Li, XiaoMeng, Yuan, YongYi, Wang, Pu, Li, Ying, Lin, SiYu, Lian, HengLi, Chen, ShiHao, Ye, YuFeng, Wang, JunJie et al (show 3 more authors)
(2024)
In vivo corneal biomechanical response to three different laser corneal refractive surgeries.
Journal of Refractive Surgery.
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Qu - Biomechanical response to 3 LVCs 2024.pdf - Author Accepted Manuscript Access to this file is restricted: awaiting official publication and publisher embargo. Download (712kB) |
Abstract
Purpose: To compare the effects of the three common refractive surgeries on corneal biomechanics. Methods: Two hundred and seven refractive surgery patients were included in this study, of which 65 received tPRK, 73 accepted FS-LASIK, and 69 underwent SMILE. Each patient had biomechanical measurements using the Corvis ST before (pre) surgery, and at 3 months (pos3m) and 6 months post-surgery (pos6m). The measurements included 5 parameters expected to be associated with corneal biomechanics, namely DAR2, IIR, SPA1, HCT and SSIv2. The variations in these parameters post-surgery among the three surgeries, and their relationship with corneal thickness (CCT) and intraocular pressure measured by the Dynamic Contour Tonometer (DCT-IOP) were analyzed. Results: SP-A1 decreased significantly from pre to pos3m in all three groups, while DAR2 and IIR increased significantly – all indicating stiffness losses. Between pos3m and pos6m, the results were inconsistent with DAR2 decreasing (indicating stiffness increases) and IIR increasing (denoting stiffness decreases) in the FS-LASIK and SMILE groups. The decrease in SSIv2 – the only measure of corneal material stiffness – post-surgery was comparatively less pronounced at both pos3m and pos6m. On the other hand, HCT remained generally stable after all three surgeries. Unlike DAR2, IIR and SP-A1, the changes post-surgery in stiffness parameters HCT and SSIv2 were independent of the corresponding changes in both DCT-IOP and CCT. Conclusions: Among the stiffness parameters considered, SSIv2 was not correlated with CCT or DCT-IOP, and holds promise for representing the corneal material stiffness and how it remains largely unaffected by refractive surgeries. Overall, FS-LASIK had the most significant impact on corneal stiffness, followed by SMILE, and finally tPRK.
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science and Engineering > School of Engineering |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Mar 2024 08:39 |
| Last Modified: | 25 Mar 2024 08:39 |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179843 |
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