Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis.

Shah, Nishel M, Charani, Esmita ORCID: 0000-0002-5938-1202, Ming, Damien ORCID: 0000-0003-3125-6378, Cheah, Fook-Choe and Johnson, Mark R (2024) Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis. Journal of intensive medicine, 4 (1). pp. 46-61.

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Official URL: http://dx.doi.org/10.1016/j.jointm.2023.07.006

Abstract

Pregnant and postnatal women are a high-risk population particularly prone to rapid progression to sepsis with significant morbidity and mortality worldwide. Moreover, severe maternal infections can have a serious detrimental impact on neonates with almost 1 million neonatal deaths annually attributed to maternal infection or sepsis. In this review we discuss the susceptibility of pregnant women and their specific physiological and immunological adaptations that contribute to their vulnerability to sepsis, the implications for the neonate, as well as the issues with antimicrobial stewardship and the challenges this poses when attempting to reach a balance between clinical care and urgent treatment. Finally, we review advancements in the development of pregnancy-specific diagnostic and therapeutic approaches and how these can be used to optimize the care of pregnant women and neonates.

Item Type:	Article
Uncontrolled Keywords:	Antibiotic stewardship, Cardiovascular, Immunology, Personalised medicine, Pregnancy, Sepsis
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	26 Mar 2024 10:08
Last Modified:	26 Mar 2024 15:29
DOI:	10.1016/j.jointm.2023.07.006
Open Access URL:	https://doi.org/10.1016/j.jointm.2023.07.006
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179932