Combination of deep XLMS with deep learning reveals an ordered rearrangement and assembly of a major protein component of the vaccinia virion.

Mirzakhanyan, Yeva ORCID: 0000-0002-4276-8937, Jankevics, Andris ORCID: 0000-0003-2095-6846, Scheltema, Richard A ORCID: 0000-0002-1668-0253 and Gershon, Paul David ORCID: 0000-0002-4904-9193 (2023) Combination of deep XLMS with deep learning reveals an ordered rearrangement and assembly of a major protein component of the vaccinia virion. mBio, 14 (5). e0113523-.

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Official URL: http://dx.doi.org/10.1128/mbio.01135-23

Abstract

<h4>Importance</h4>An outstanding problem in the understanding of poxvirus biology is the molecular structure of the mature virion. Via deep learning methods combined with chemical cross-linking mass spectrometry, we have addressed the structure and assembly pathway of P4a, a key poxvirus virion core component.

Item Type:	Article
Uncontrolled Keywords:	Humans, Poxviridae, Vaccinia virus, Virion, Vaccinia, Deep Learning
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	26 Mar 2024 10:19
Last Modified:	26 Mar 2024 15:29
DOI:	10.1128/mbio.01135-23
Open Access URL:	https://doi.org/10.1128/mbio.01135-23
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179942