Improving in vivo assays in snake venom and antivenom research: A community discussion

Marriott, Amy ORCID: 0000-0002-4806-9539, Casewell, Nicholas, Lilley, Elliot, Gutiérrez, José-María and Ainsworth, Stuart ORCID: 0000-0002-0199-6482 (2024) Improving in vivo assays in snake venom and antivenom research: A community discussion. F1000Res, 13. 192-.

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Abstract

On the 26th January 2023, a free to attend, ‘improving in vivo snake venom research: a community discussion’ meeting was held virtually. This webinar brought together researchers from around the world to discuss current neutralisation of venom lethality mouse assays that are used globally to assess the efficacy of therapies for snakebite envenoming. The assay’s strengths and weaknesses were highlighted, and we discussed what improvements could be made to refine and reduce animal testing, whilst supporting preclinical antivenom and drug discovery for snakebite envenoming. This report summarises the issues highlighted, the discussions held, with additional commentary on key perspectives provided by the authors.

Item Type:	Article
Uncontrolled Keywords:	3Rs, Antivenom, Lethality, NAMs, Preclinical assays, Venom, Antivenins, Animals, Snake Venoms, Mice, Snake Bites, Humans
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	03 Apr 2024 13:58
Last Modified:	10 May 2024 12:53
DOI:	10.12688/f1000research.148223.1
Open Access URL:	https://f1000research.com/articles/13-192
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180048